Anti-mouse FGF-21 Antibody, Rabbit pAb

Anti-mouse FGF-21 Antibody, Rabbit pAb

SKU: 12180

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Polyclonal Antibody against Mouse FGF-21

Application: ELISA

Size: 0.1 mg

Host: Rabbit

  • INTRODUCTION

    Fibroblast growth factor 21 (FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions. In murine models, FGF-21 is predominantly expressed in liver, but is also expressed in adipose tissue and pancreatic β-cells. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when administered to diabetic rodents. When administered daily for 6 weeks to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin and glucagon. Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance.

  • IMMUNOGEN

    Recombinant full-length mouse FGF-21 expressed in E.coli.

  • SPECIFICITY

    The antibody detects circular mouse FGF-21 in western blot and ELISA.

  • FORMULATION

    Liquid in phosphate-buffered saline (PBS).

  • STORAGE

    Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • APPLICATION/ USAGE

    ELISA - This antibody can be used at 2 μg/mL with the appropriate secondary reagents to detect mouse FGF-21.

    Western blot - This antibody can be used at 0.2-0.5 μg/mL with the appropriate secondary reagents to detect mouse FGF-21.

  • PURIFICATION

    Antigen affinity-purified

  • PUBLICATIONS CITING THIS PRODUCT

    1. Li H, Gao Z, Zhang J, Ye X, Xu A, Ye J, Jia W. Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. Diabetes. 2012 Apr 1;61(4):797-806.
    2. Liu Y, Palanivel R, Rai E, Park M, Gabor TV, Scheid MP, Xu A, Sweeney G. Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice. Diabetes. 2015 Jan 1;64(1):36-48.
    3. Liu J, Yang K, Yang J, Xiao W, Le Y, Yu F, Gu L, Lang S, Tian Q, Jin T, Wei R. Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output. EBioMedicine. 2019 Mar 1;41:73-84.
    4. Cheng Y, Zhang X, Ma F, Sun W, Wang W, Yu J, Shi Y, Cai L, Xu Z. The role of AKT2 in the protective effect of fenofibrate against diabetic nephropathy. International journal of biological sciences. 2020;16(4):553.
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