Glutamic Acid Decarboxylase (GAD65) Autoantibody ELISA kit
For the quantitative determination of human anti-GAD65 ELISA (IgG class antibodies) in serum
Immunodiagnostics (IMD) GAD65 auto-antibody ELISA kit is dedicated to the in vitro determination and quantitative of GAD65 auto-antibody. This product is recommended for clinical and research use only. GAD65 autoantigen is one of the most important serological markers for diagnostics of insulin-dependent diabetes mellitus (IDDM) and latent autoimmune diabetes (LADA). Besides GAD65, autoantibodies to beta-cells also included ICA, IA2 and ZnT8. IDDM is highly prevalent in Europe and North American. Epidemiological study shows that there is a gradual rise of prevalence in China, approximately 10% of Chinese people are suffering from IDDM. Furthermore, GAD65 is also relevant with Stiffman syndrome(SMS).
Clinical Specificity and sensitivity
In the clinical validation at IMD, the IMD GADA ELISA kit achieve 82.5% sensitivity (n=40) and 91.12% (n=80) specificity.
Inter assay precision
Intra assay precision
Stenström, Gunnar, et al. "Latent autoimmune diabetes in adults: definition, prevalence, β-cell function, and treatment." Diabetes 54.suppl 2 (2005): S68-S72.
Schmidli, Robert S., Peter G. Colman, and Ezio Bonifacio. "Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies: the Second International GADAB Workshop." Diabetes 44.6 (1995): 636-640.
Moffett, Ashley, et al. "Variation of maternal KIR and fetal HLA-C genes in reproductive failure: too early for clinical intervention." Reproductive biomedicine online 33.6 (2016): 763-769.