• Glutamic Acid Decarboxylase (GAD65) Autoantibody ELISA kit

    SKU: 31840

     

    For the quantitative determination of human anti-GAD65 ELISA (IgG class antibodies) in serum

    • INTRODUCTION

      Immunodiagnostics (IMD) GAD65 auto-antibody ELISA kit is dedicated to the in vitro determination and quantitative of GAD65 auto-antibody. This product is recommended for clinical and research use only. GAD65 autoantigen is one of the most important serological markers for diagnostics of insulin-dependent diabetes mellitus (IDDM) and latent autoimmune diabetes (LADA). Besides GAD65, autoantibodies to beta-cells also included ICA, IA2 and ZnT8.  IDDM is highly prevalent in Europe and North American. Epidemiological study shows that there is a gradual rise of prevalence in China, approximately 10% of Chinese people are suffering from IDDM.  Furthermore, GAD65 is also relevant with Stiffman syndrome(SMS).

    • Clinical Evaluation

      Clinical Specificity and sensitivity

      In the clinical validation at IMD, the IMD GADA ELISA kit achieve 82.5% sensitivity (n=40) and 91.12% (n=80) specificity.

       

      Inter assay precision

      Sample

      IU/ml (n=6)

      CV(%)

      A

      120

      6.75%

      B

      18

      6.66%

      C

      5

      7.26%

       

      Intra assay precision

      Sample

      IU/ml (n=6)

      CV(%)

      A

      120

      6.61%

      B

      18

      4.63%

      C

      5

      9.65%

       

    • References:

      Stenström, Gunnar, et al. "Latent autoimmune diabetes in adults: definition, prevalence, β-cell function, and treatment." Diabetes 54.suppl 2 (2005): S68-S72.

       

      Schmidli, Robert S., Peter G. Colman, and Ezio Bonifacio. "Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies: the Second International GADAB Workshop." Diabetes 44.6 (1995): 636-640.

       

      Moffett, Ashley, et al. "Variation of maternal KIR and fetal HLA-C genes in reproductive failure: too early for clinical intervention." Reproductive biomedicine online 33.6 (2016): 763-769.

    • DATA SHEET

    $400.00Price

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