Human Proteinase 3 (PR3) ELISA

Human Proteinase 3 (PR3) ELISA

SKU: 31300

Assay range :   0.078 - 10 ng/ml

Size:                  96T/Kit

 

The following standard curve is provided for demonstration only. A standard curve should be generated for each set of sample assay.

  • INTRODUCTION

    Proteinase 3 (PR3), also known as myeloblastin, Wegener autoantigen, PRTN3 and NP- 4, is one of the hematopoietic serine proteases localized in the primary granules of polymorphonuclear neutrophils (PMNs). The primary function of PR3 is recognized as to participate in direct intracellular killing of phagocytosed pathogens in phagolysosomes and degradation of extracellular matrix components at inflammatory. PR3 has also been proven to be able to process some pro-inflammatory cytokines, such as IL- 1β, IL-18 and TNF-α, activate mitogen activated protein kinase (MAPK) signaling through proteinase activated receptor-1 (PAR1), and induce endothelial cell apoptosis through NF-κB signaling pathways. PR3 is identified as the target autoantigen of anti-neutrophil cytoplasmic autoantibodies (ANCA) in Wegener granulomatosis. Increased PR3 levels have been reported in patients with acute myocardial infarction, and in subjects with type 1 diabetes.

  • ASSAY CHARACTERISTICS

     

  • Publications Citing Human Adiponectin ELISa kit:

     

  • DATA SHEET

$400.00Price

©2019 by ImmunoDiagnostics Limited.