©2019 by ImmunoDiagnostics Limited.

Adiponectin (mouse), rabbit PAb

SKU: 12010
Application  :  ELISA, WB
Size              :  0.1 mg

  • INTRODUCTION

    Adiponectin, also termed gelatin-binding protein-28 (GBP28), AdipoQ, ACP30(Acrp30), or apM, is a major adipocyte-secreted adipokine which abundantly presentin the circulation as three distinct oligomeric complexes: LMW(67kDa),MMW(167kDa) and HMW(300kDa) adiponectin. Its levels are decreased in insulinresistant, diabetes and cardiovascular disease. Conversely, elevation of circulatingadiponectin concentrations can alleviate various vascular dysfunctions in animalmodels, suggesting this adipokine exerts vasculoprotective effects.

    In addition,adiponectin may also be of importance in the development and progression ofseveral malignancies.

     

  • DATA SHEET

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  • ISOTYPE/PREPARATION

    Rabbit crude IgG was purified by protein-G column

  • IMMUNOGEN

    Recombinant full-length human adiponectin expressed in mammalian cells

  • SPECIFICITY

    The antibody detects three types of circular human adiponectin and monomer (30kDa) adiponectin

  • FORMULATION

    Solution in PBS.

  • STORAGE

    Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • APPLICATION/ USAGE

    Western blot - This antibody can be used at 0.1 – 0.2 µg/mL with the appropriate secondary reagents to detect mouse/rat adiponectin.

    ELISA - This antibody can be used at 0.5 - 1.0 µg/mL with the appropriate secondary reagents to detect mouse/rat adiponectin.

    Immunoprecipitation - See reference [1], [2]

  • PUBLICATIONS CITING IMD ADIPONECTIN:

    1- Hui X, Gu P, Zhang J, et al. Cell Metab. 2015; 22(2): 279-290.
     2- Zhang, Xu, et al. Cell Death Differ. 2017; 24(2):225-237.

  • REFERENCES

    [1] Xu A, et al. (2005) Testosterone selectively reduces the high molecular weight form of adiponectin by
    inhibiting its secretion from adipocytes. J. Biol. Chem. 280, 18073–18080
    [2] Xu A, et al. (2008) Selective Elevation of Adiponectin Production by the Natural Compounds Derived
    from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice. Endocrinology.
    [Epub ahead of print]
    [3] Xu A, et al. (2004) Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus
    protease inhibitor ritonavir in mice. Endocrinology. 145(2):487-94
    [4] Wang Y, et al. (2008) Post-translational modifications of adiponectin: mechanisms and functional
    implications. Biochem J. 409(3):623-33

$200.00Price