CRP antibody

SKU: 11120-S10

Size: 1mg            Host: Rabbit

  • INTRODUCTION

    C-reactive protein (CRP) is a circulating protein mainly secreted from the liver. This acute phase protein consists of five identical non-glycosylated subunits of 23 kDa, that give rise to a symmetrically arranged globular protein with molecular weight of approximately 120 kDa.1 It has long been recognized that CRP is closely related to immunology, inflammation and host defence, as a result it has been used as an inflammatory marker. There is accumulating evidence suggesting the important role that CRP plays in mediating cardiovascular diseases (CVD) and type 2 diabetes.2-4 Normally CRP is presenting only in a trace amount in circulation (<1 mg/ml)5-6 but can increase over 1,000-fold under acute inflammatory state. Individual with blood CRP levels <1 mg/ml, 1-3 mg/ml and >3 mg/ml is considered to have low, moderate and high risk, respectively, of CVD and myocardial infraction.7 Therefore, blood CRP level has become a promising measure of CVD risk.8-9

     

  • DATA SHEET

  • PREPARATION

    Rabbit IgG was purified by protein-G column

  • IMMUNOGEN

    Native Human C- reactive Protein (CRP)

  • SPECIFICITY

    The antibody detects human CRP.

  • FORMULATION

    Solution in PBS.

  • APPLICATION/ USAGE

    Standard ELISA, Immunoturbidimetric assay

  • QUALITY CONTROL TEST

    BCA to determine quantity of the antibody.

  • STORAGE

     

    Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • REFERENCE

    1- Thompson D., Pepys M.B. and Wood S.P. (1999) Structure7, 169-177.

    2- Festa A, D’Agostino R. Jr., Tracy R.P. and Haffner S.M. (2002) Diabetes51, 1131-1137.

    3- Verma S. and Yeh E.T. (2003) Am J Physiol285, R1253-R1258.

    4- Jialal I., Devaraj S. and Venugopal S.K. (2004) Hypertension44, 6-11.

    5- Kindmark C.O. (1972) Scand J Clin Lab Invest29, 407-411.

    6- Macy E.M., Hayes T.E. and Tracy R.P. (1997) Clin Chem43, 52-58.

    7- Ridker P.M. (2004) Am Heart Hosp J2 (4 Suppl 1), 4-9.

    8- Benzaquen l.R., Yu H. and Rifai N. (2002) Crit Rev Clin Lab Sci39, 459-497.

    9- Pearson T.A. et al., (2003) Circulation107, 499-511.

$400.00Price

©2019 by ImmunoDiagnostics Limited.