FABP4 MAb, clone 2C10

SKU: 21030

 

Application  :  ELISA capture

Size              :  1 mg

  • INTRODUCTION

    Fatty-acid binding protein 4 (FABP4), also termed adipocyte fatty-acid binding protein (A-FABP), or aP2, is a novel adipocyte-expressed factor which accounted for ~6% of total cellular proteins. Several animal experiments suggested that FABP-4 plays a key role in the link between obesity and various features of metabolic syndrome.1 Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease.2 Studies in human found FABP-4 serum levels were significantly increased in overweight and obese subjects, which predicted the risk to develop a metabolic syndrome and type 2 diabetes.3-4 Additionally, serum FABP-4 levels were associated with nonalcoholic fatty liver disease, carotid atherosclerosis and coronary artery disease. 5-7

  • DATA SHEET

  • IMMUNOGEN

    Recombinant full-length human FABP4 in E.coli.

  • HOST

    Mouse

  • ISOTYPE/ LIGHT CHAIN TYPE

    Mouse IgG1/ Kappa

  • STORAGE

    Store at –20°C.

  • APPLICATION/ USAGE

    This antibody can be used as a capture antibody in a human FABP4 ELISA.

  • PURIFICATION METHOD

    Affinity chromatography on a column with immobilized protein G.

     

  • SPECIES REACTIVITY

     Human. Not yet tested in other species

  • REFERENCE

    1] Makowski L, et al. (2004) J Nutr. 134: 2464S–2468S. 

    [2] Makowski L, et al. (2001) Nat Med. 7: 699–705. 

    [3] Xu A, et al. (2006). Clin Chem. 52(3):405-13. 

    [4] Xu A, et al. (2007). Circulation. 115:1537–1543. 

    [5] Rhee EJ, et al. (2009) Eur J Endocrinol. 160(2):165-72. 

    [6] Tso AW, et al. (2007) Diabetes Care. 30(10):2667-72 

    [7] J. Hyun Koh, et al. (2009) Diabetes Care. 32(1): 147 - 152.

$225.00Price

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