Anti-human FABP4 Antibody, Mouse mAb, clone 2C10
Fatty acid binding protein 4 (FABP4), also termed adipocyte fatty acid binding protein (A-FABP), or aP2, is a novel adipocyte-expressed factor which accounted for ~6% of total cellular proteins. Several animal experiments suggested that FABP-4 plays a key role in the link between obesity and various features of metabolic syndrome. Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. Studies in human found FABP-4 serum levels were significantly increased in overweight and obese subjects, which predicted the risk to develop a metabolic syndrome and type 2 diabetes.[3-4] Additionally, serum FABP-4 levels were associated with nonalcoholic fatty liver disease, carotid atherosclerosis and coronary artery disease. [5-7]
Recombinant full-length human FABP4 in E.coli.
ISOTYPE/ LIGHT CHAIN TYPE
Mouse IgG1/ Kappa
Store at –20°C.
This antibody can be used as a capture antibody in a human FABP4 ELISA.
Affinity chromatography on a column with immobilized protein G.
Human. Not yet tested in other species
1] Makowski L, et al. (2004) J Nutr. 134: 2464S–2468S.
 Makowski L, et al. (2001) Nat Med. 7: 699–705.
 Xu A, et al. (2006). Clin Chem. 52(3):405-13.
 Xu A, et al. (2007). Circulation. 115:1537–1543.
 Rhee EJ, et al. (2009) Eur J Endocrinol. 160(2):165-72.
 Tso AW, et al. (2007) Diabetes Care. 30(10):2667-72
 J. Hyun Koh, et al. (2009) Diabetes Care. 32(1): 147 - 152.