FABP4 (mouse), rabbit PAb

FABP4 (mouse), rabbit PAb

SKU: 12030

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Fatty-acid binding protein 4 (mouse), rabbit polyclonal antibody

Application  :  WB, IP

Size              :  100 ug

  • INTRODUCTION

    Fatty-acid binding protein 4(FABP4), also termed adipocyte fatty-acid binding protein(A-FABP), or aP2, is a novel adipocyte-expressed factor which accounted for ~6% of total cellular proteins. Several animal experiments suggested that FABP-4 plays a key role in the link between obesity and various features of metabolic syndrome. Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. Studies in human found FABP-4 serum levels were significantly increased in overweight and obese subjects, which predicted the risk to develop a metabolic syndrome and type 2 diabetes. Additionally, serum FABP-4 levels were associated with carotid atherosclerosis and coronary artery disease.

  • DATA SHEET

  • IMMUNOGEN

    Recombinant full-length Mouse FABP4 expressed in E.coli.

  • SPECIFICITY

    The antibody detects Mouse FABP4.

  • FORMULATION

    Solution in PBS.

  • STORAGE

    Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • APPLICATION/ USAGE

    Western blot - This antibody can be used at 0.5 - 1 µg/mL with the appropriate secondary reagents to detect mouse FABP4.

    Immunoprecipitation, ELISA and immunocytochemistry are not tested.

     

  • ISOTYPE/PREPARATION

    Rabbit crude IgG was purified by protein-G column.

  • REFERENCE:

    [1] Xu A, et al. (2006) Adipocyte Fatty Acid–Binding Protein Is a Plasma Biomarker Closely Associated with Obesity and Metabolic Syndrome. Clin Chem. 52(3):405-13.

    [2] Xu A, et al. (2007) Circulating adipocyte–fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation. 115:1537–1543.

    [3] Rhee EJ, et al. (2009) The association of serum adipocyte fatty acid-binding protein with coronary artery disease in Korean adults. Eur J Endocrinol. 160(2):165-72.

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