FABP5 (human), rabbit PAb
Fatty-acid binding protein 5 (human), rabbit polyclonal
Application : WB, IP
Size : 0.1 mg
INTRODUCTION
The fatty-acid-binding proteins (FABPs) are a family of carrier proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. The fatty acid binding protein 4 (FABP-4) and fatty acid binding protein 5(FABP5) are closely related and both are expressed in adipocytes. Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. While mice over expressing FABP5 in adipose have reduced insulin sensitivity
DATA SHEET
IMMUNOGEN
Recombinant full-length human FABP5 expressed in E.coli.
SPECIFICITY
The antibody detects human FABP5
FORMULATION
Solution in PBS.
STORAGE
Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
APPLICATION/ USAGE
Western blot - This antibody can be used at 0.5 - 2 μg/mL with the appropriate secondary reagents to detect human FABP5.
Immunoprecipitation, ELISA and immunocytochemistry are not tested.
ISOTYPE/PREPARATION
Rabbit crude IgG was purified by protein-G column
REFERENCE:
[1] Xu A, et al. (2006) Adipocyte Fatty Acid–Binding Protein Is a Plasma Biomarker Closely Associated with Obesity and Metabolic Syndrome. Clin Chem. 52(3):405-13.
[2] Xu A, et al. (2007) Circulating adipocyte–fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation. 115:1537–1543.
[3] Rhee EJ, et al. (2009) The association of serum adipocyte fatty acid-binding protein with coronary artery disease in Korean adults. Eur J Endocrinol. 160(2):165-72.