Anti-human FGF-21 Antibody, Rabbit pAb
Polyclonal Antibody against Human FGF-21
Size: 0.1 mg
Fibroblast growth factor 21 (FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions [1,2]. In murine models, FGF-21 is predominantly expressed in liver, but also expressed in adipose tissue and pancreatic β-cells [3,4]. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents . When administered daily for 6 weeks to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin and glucagon . Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance .
Recombinant full-length human FGF-21 expressed in E.coli.
The antibody detects circular human FGF-21.
Liquid in phosphate-buffered saline (PBS).
Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
ELISA - The antibody can be used at 2 μg /mL with the appropriate secondary reagents to detect human FGF21.
 Kharitonenkov A, Shiyanova TL, et al. (2005) J Clin Invest; 115: 1627– 1635
 Badman MK, Pissios P, et al. (2007) Cell Metab; 5: 426– 437
 Nishimura T, Nakatake Y, et al. (2000) Biochim Biophys Acta; 1492: 203– 206
 Kurosu H, Choi M, et al. (2007) J Biol Chem; 282: 26687– 26695
 Kharitonenkov A, Shiyanova TL, et al. (2005) J. Clin. Invest. 115: 1627–35.
 Kharitonenkov A, Wroblewski VJ, et al. (2007) Endocrinology;148:774-81
 Chavez AO, Molina-Carrion M, et al. (2009) Diabetes Care; 32:1542-6.
PUBLICATIONS CITING THIS PRODUCT
- Ye D, Li H, Wang Y, Jia W, Zhou J, Fan J, Man K, Lo C, Wong C, Wang Y, Lam KS. Circulating fibroblast growth factor 21 is a sensitive biomarker for severe ischemia/reperfusion injury in patients with liver transplantation. Scientific reports. 2016 Jan 25;6(1):1-9.