©2019 by ImmunoDiagnostics Limited.

Human FGF-19, rabbit Pab

SKU: 11200

  Size: 100 ug                         Host: Rabbit

  • INTRODUCTION

    Fibroblast growth factor 19 (FGF-19) is a member of a subfamily of FGFs that includes FGF-21 and FGF-23, each member functions as an important regular of nutrient metabolism [1]. The primary source of endocrine FGF-19 is  the ileum, bile acids release into the intestine  after a meal to induce expression of FGF-19 [2]. Circulating FGF-19 plays an important role in maintaining proper bile acid homeostasis [3].  Several pharmacologic studies in hyperglycaemic, obese animal models have shown that FGF-19 can improve metabolic rate and lower serum glucose and hepatic triglyceride and cholesterol   levels [4]-[5].   Like insulin, FGF-19 functions as postprandial hormone to govern hepatic protein synthesis, glycogen synthesis and gluconeogenesis, but does not stimulate lipogenesis [6].

  • DATA SHEET

  • IMMUNOGEN

    Recombinant full-length human FGF-19 expressed in E.coli.

  • SPECIFICITY

    The antibody detects circular human FGF-19.

  • FORMULATION

    Solution in PBS, azide free.

  • STORAGE

    Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • APPLICATION/ USAGE

    ELISA- the antibody can be used as capture and detection antibody in ELISA. 


    Western blot, Immunoprecipitation and immunocytochemistry are not tested.

  • PREPARATION

    Immunoaffinity chromatography on a column with immobilized recombinant human FGF-19.

  • Publications Citing IMD FGF-21(mouse), rabbit PAb

    Liu Y, Palanivel R, Rai E, et al. Diabetes. 2015; 64(1): 36-48.
     Li H, Gao Z, Zhang J, et al. Diabetes. 2012; 61(4): 797-806.
     

  • REFERENCES

    [1] Beenken A, et al. (2009) Nat Rev Drug Discov; 8: 235– 253.

    [2] Inagaki T, et al. (2005) Cell Metab; 2: 217– 225.

    [3] Lundasen T, et al. (2006) J Inter Med;260:530-536.

    [4] Tomlinston E, et al.  (2002) Endocrinology; 143: 1741-1747.

    [5] Fu L, et al. (2004) Endocrinology; 145: 2594-2603.

    [6] Kir S, et al. (2011) Science; 331: 1621– 1624.

$240.00Price