Anti-human FGF-19 Antibody, Rabbit pAb
Fibroblast growth factor 19 (FGF-19) is a member of a subfamily of FGFs that includes FGF-21 and FGF-23, each member functions as an important regular of nutrient metabolism . The primary source of endocrine FGF-19 is the ileum, bile acids release into the intestine after a meal to induce expression of FGF-19 . Circulating FGF-19 plays an important role in maintaining proper bile acid homeostasis . Several pharmacologic studies in hyperglycaemic, obese animal models have shown that FGF-19 can improve metabolic rate and lower serum glucose and hepatic triglyceride and cholesterol levels -. Like insulin, FGF-19 functions as postprandial hormone to govern hepatic protein synthesis, glycogen synthesis and gluconeogenesis, but does not stimulate lipogenesis .
Recombinant full-length human FGF-19 expressed in E.coli.
The antibody detects circular human FGF-19.
Solution in PBS, azide free.
Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
ELISA- the antibody can be used as capture and detection antibody in ELISA.
Western blot, Immunoprecipitation and immunocytochemistry are not tested.
Immunoaffinity chromatography on a column with immobilized recombinant human FGF-19.
Publications Citing IMD FGF-21(mouse), rabbit PAb
Liu Y, Palanivel R, Rai E, et al. Diabetes. 2015; 64(1): 36-48.
Li H, Gao Z, Zhang J, et al. Diabetes. 2012; 61(4): 797-806.
 Beenken A, et al. (2009) Nat Rev Drug Discov; 8: 235– 253.
 Inagaki T, et al. (2005) Cell Metab; 2: 217– 225.
 Lundasen T, et al. (2006) J Inter Med;260:530-536.
 Tomlinston E, et al. (2002) Endocrinology; 143: 1741-1747.
 Fu L, et al. (2004) Endocrinology; 145: 2594-2603.
 Kir S, et al. (2011) Science; 331: 1621– 1624.