Human Rentinol Binding Protein 4(RBP4) ELISA kit
Assay range : 1.56-200 ng/ml
Size : 96T/Kit
The following standard curve is provided for demonstration only. A standard curve should be generated for each set of sample assay.
Retinol binding protein 4(RBP4), originally known as a specific transport of retinol in blood, is also a novel inflammatory and insulin resistance marker. Serum RBP4 levels are elevated in insulin-resistant mice and humans with obesity and type 2 diabetes. Animal experiments found that increased secretion of RBP4 might reduces insulin-dependent glucose uptake by muscle tissue by reducing the activity of PI(3)K (phosphoinositide 3-kinase), and increased hepatic glucose output by increasing the expression of the enzyme PEPCK2 . Studies suggested that elevated serum RBP4 was associated with components of the metabolic syndrome, including increased body-mass index, waist-to-hip ratio, serum triglyceride levels, and systolic blood pressure and decreased highdensity lipoprotein cholesterol levels4 . Furthermore, circulating RBP4 concentrations were associated with subclinical cardiovascular disease, which imply that RBP4 could be involved in the development of atherosclerosis5 .
The lowest level of RBP4 that can be detected by this assay is 1.56 ng/ml.
The antibody pair used in this assay is specific to human RBP4 and does not cross-react with mouse and rat RBP4, and other cytokine or hormone molecules.
Intra-assay Precision (Precision within an assay)
Three samples of known concentration were tested 16 times on one plate.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in 10 separate assays.
Serum samples were spiked with different amounts of human RBP4 and assayed.
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