top of page
Anti-human PAI-1 Antibody, Rabbit pAb

Anti-human PAI-1 Antibody, Rabbit pAb

SKU: 11070

★ Download Datasheet PDF ★


Polyclonal Antibody against Human PAI-1

Application: ELISA, WB, IP

Size: 0.1 mg

Host: Rabbit


    Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activator, playing a major role in fibrinolysis [1,2]. PAI-1 is mainly produced by the endothelium, but is also secreted by other tissue types, such as adipose tissue [3]. It is normally present at low levels in plasma and tissue, but its expression and release are increased in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome [4]. PAI-1 is also involved in the pathophysiology of renal, pulmonary, cardiovascular, and metabolic diseases [5-8]. Elevated local or systemic PAI-1 can also exacerbate such pathologic conditions.


    Recombinant full-length human PAI-1 expressed in E.coli.


    The antibody detects circular human PAI-1 in ELISA.


    Rabbit crude IgG was purified by protein-G chromatography.


    Liquid in phosphate-buffered saline (PBS).


    Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.


    ELISA - This antibody can be used in ELISA with the appropriate secondary reagents to detect human PAI-1.


    1. Lijnen HR, et al. (1995) Baillieres Clin Haematol. 8: 277–290
    2. Dellas C, et al. (2005) Thromb Haemost. 2005; 93: 631–640
    3. Binder BR, et al. (2002) News Physiol Sci 17:56-61
    4. Vague P, et al. (1986) Metabolism. 35: 250–253
    5. Sobel Be, et al. (2003) Arterioscler Thromb Vasc Biol. 23: 1979–1989
    6. Eitzman DT, et al. (1996) J Clin Invest. 97(1):232-7
    7. Gils A, et al. (2004) Thromb. Haemost. 91 (3): 425–37
    8. Cale JM, Lawrence DA. (2007) Curr Drug Targets. 8(9):971-81

The currency used on this website is United States Dollars (USD). All prices are displayed and transactions are processed in USD. For orders outside Hong Kong or if you would like to have other currencies available, please contact us for a quote.

bottom of page