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Retinol binding protein 4, rabbit PAb

SKU: 12060

Retinol binding protein 4 (human), rabbit polyclonal

Application  :  WB

Size              :  0.1 mg

  • INTRODUCTION

    Retinol binding protein 4(RBP4), originally known as a specific transport of retinol in blood, is also a novel inflammatory and insulin resistance marker. Serum RBP4 levels are elevated in insulin resistant mice and humans with obesity and type 2 diabetes. Animal experiments found that increased secretion of RBP4 might reduce insulin-dependent glucose uptake by muscle tissue by reducing the activity of PI(3)K (phosphoinositide 3-kinase), and increased hepatic glucose output by increasing the expression of the enzyme PEPCK2. Studies suggested that elevated serum RBP4 was associated with components of the metabolic syndrome, including increased body-mass index, waist-to-hip ratio, serum triglyceride levels, and systolic blood pressure and decreased high-density lipoprotein cholesterol levels. Furthermore, circulating RBP4 concentrations were associated with subclinical cardiovascular disease, which imply that RBP4 could be involved in the development of atherosclerosis.

  • DATA SHEET

  • IMMUNOGEN

    Recombinant full-length mouse RBP4 expressed in E.coli.

  • SPECIFICITY

    The antibody detects mouse RBP4.

  • FORMULATION

    Solution in PBS.

  • STORAGE

    Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • APPLICATION/ USAGE

    Western blot - This antibody can be used as primary antibody in western blot assay to detect mouse RBP4

    ELISA - This antibody can be used in ELISA with the appropriate secondary reagents to detect mouse RBP4

  • ISOTYPE/PREPARATION

    Rabbit specific IgG was purified by Mouse RBP4 affinity chromatography

  • REFERENCE:

    1. McIntosh, I., and Bishop, J. O. (1989) Mol. Cell. Biol. 9, 2202–2207.

    2. Zhou Y, Jiang L, Rui L. (2009) J Biol Chem. 284(17):11152-9.

     

$200.00Price