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TNF-α His Tag, Human

TNF-α His Tag, Human

SKU: UA040062

★ Download Datasheet PDF ★

★ Download MSDS ★





Expression System:



18.5 kDa (reducing)



Cat No.



1 EU/μg


>95% as determined by SDS-PAGE



    Tumor necrosis factor α (TNF alpha) is an effective pro-inflammatory cytokine, which can kill and inhibit tumor cells. It is mainly produced by activated macrophages and can also be secreted by other types of cells, such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils and neuronal tissues. The members of TNF alpha family exert their cellular effect through two distinct surface receptors of the TNF receptor family, TNFR1 and TNFR2. The pleiotropic biological effects of TNF can be attributed to its ability to simultaneously activate multiple signaling pathways in cells. TNF-induced NF-κB activation promotes the growth, invasion and metastasis of cancer cells.

  • Amino Acid Sequence

    Val77-Leu233, with N-terminal 8*His

  • Physical Appearance:

    Lyophilized powder

  • Buffer

    20mM Tris, 150mM NaCl, 2mM TCEP, pH8.5

  • Reconstitution

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • Stability and Storage

    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
    • 1 week, 2 to 8 °C under sterile conditions after reconstitution.

    Note: Please avoid repeated freeze-thaw cycles


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