Wide Range C-Reactive Protein Turbidimetric Immunoassay Reagent Kit
The following standard curve is provided for demonstration only. A standard curve should be generated for each set of sample assay.
C-Reactive Protein (CRP), also known as PTX1, and pentraxin-related, is an annular pentameric protein produced from hepatic. The mechanism is when the body is infected or the tissue is damaged, macrophages and T cells are activated, producing interleukin-6, interleukin-1, tumor necrosis factor and other cytokines and mediators. Factors and mediators reach the liver, stimulating the synthesis of CRP by hepatocytes and epithelial cells. CRP is used mainly as an inflammation marker. Apart from liver failure, there are few known factors that interfere with CRP production.
Many pharmacological studies demonstrated that this protein possesses potent anti-diabetic, anti-atherogenic and anti-inflammatory functions. Supplement of adiponectin protein can decrease blood glucose, improve insulin sensitivity, alleviate fatty liver and prevent atherosclerosis. Decreased circulating levels of plasma adiponectin (hypoadiponectinaemia) are associated with increased body mass index (BMI), and decreased insulin sensitivity.
The sensitivity is defined as the lower limit of detection and is estimated as the mean of the blank sample plus three times the SD obtained from the blank sample. The sensitivity of CRP assay is 0.1mg/L.
The precision of the CRP assay is < 10% CV. Four samples consisting of two CRP controls and two serum based panels were assayed 20 times separately.
The CRP assay is linear between 0.1 mg/L to 300 mg/L.
No interference was detected with hemoglobin up to 5 g/L, conjugated bilirubin up to 300 mg/L, free bilirubin up to 300 mg/L, and up to 5g/L lipid emulsion.