Angiopoietin-like protein 4, Rabbit pAb

Angiopoietin-like protein 4, Rabbit pAb

SKU: 11020

 Size: 100 ug                           Host: Rabbit

  • INTRODUCTION

    Angiopoietin-like protein 4 (ANGPTL4), also known as PPARγ angiopoietinrelated protein, fasting-induced adipose factor, or hepatic fibrinogen /angiopoietin-related protein (HFARP), is a secreted adipokine predominantly expressed in adipose tissue and liver. The experimental results show that ANGPTL4 is a blood-borne hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. Serum levels of ANGPTL4 were decreased in patients with type 2 diabetes. In animal experiments, ANGPTL4 treatments might reduce hyperglycemia, and improve glucose tolerance by decreasing hepatic glucose production and enhancing insulin-mediated inhibition of gluconeogenesis. However, the molecular mechanisms underlying its metabolic actions remain elusive.

     

  • DATA SHEET

  • ISOTYPE/PREPARATION

    Rabbit crude IgG was purified by protein-G column

  • IMMUNOGEN

    Recombinant full-length human ANGPTL4 expressed in E.coli

  • SPECIFICITY

    The antibody detects human ANGPTL4

  • FORMULATION

    Solution in PBS.

  • STORAGE

    Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • APPLICATION/ USAGE

    Western blot - This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect human ANGPTL4.

    ELISA - This antibody can be used at 0.5 - 1.0 μg/mL with the appropriate secondary reagents to detect human ANGPTL4.

  • PUBLICATIONS CITING IMD ADIPONECTIN:

     1- Hui X, Gu P, Zhang J, et al. Cell Metab. 2015; 22(2): 279-290.
     2- Zhang, Xu, et al. Cell Death Differ. 2017; 24(2):225-237.

  • REFERENCES

    [1] Xu A, et al. (2005) Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J. Biol. Chem. 280, 18073–18080

    [2] Wang Y, et al. (2007) Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice. Mol Endocrinol. 21(4):972-86.

$200.00Price

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