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Zinc Transporter-8 (ZnT8) Autoantibody ELISA kit from ImmunoDiagnostics

Zinc Transporter-8 (ZnT8) Autoantibody ELISA kit from ImmunoDiagnostics

SKU: 31870

★ Download Datasheet PDF ★

 

Kit Size: 96 wells/Kit

 

  • INTRODUCTION

    ZnT8 autoantibodies are important serological markers for diagnosing type 1 diabetes mellitus (T1D). ZnT8 is found in pancreatic beta cells and plays a role in regulating insulin secretion. ZnT8 autoantibodies primarily target the C-terminal domain of ZnT8 (residues 268-369). In
    the human population, gene polymorphism at the codon for the 325th amino acid leads to the expression of three protein variants: Arginine (R) 325, Tryptophan (W) 325, and rarely Glutamine (Q) 325. ZnT8 Ab can be specific to the R325 or W325 variant or non-specific to residue 325. Sera that reacts exclusively with the Q allele is extremely uncommon  The IMD ZnT8 Ab ELISA is capable of detecting and quantifying autoantibodies specific to R325, W325, or non-specific to residue 325 variants.

  • ASSAY CHARACTERISTICS

    Clinical Evaluation

    Sensitivity

    48.72% (n=40)

    Specificity

    100% (n=77)

     

    Inter-Assay Precision

     

    Sample

    IU/ml (n=6)

    CV

    1

    450

    5.30%

    2

    40

    2.34%

    3

    10

    4.38%

     

    Intra-Assay Precision

    Sample

    IU/ml (n=20)

    CV

    1

    450

    5.46%

    2

    40

    6.31%

    3

    10

    3.2%


    Sample Type: Serum 

    Storage : 4°C

  • References:

    1. Yang, Lin, et al. "The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese." Diabetes/metabolism research and reviews 26.7 (2010): 579-584.
    2. Parsons, Douglas S., Christer Hogstrand, and Wolfgang Maret. "The C‐terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant." The FEBS Journal 285.7 (2018): 1237-1250.
$600.00Price

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