LCN2 (human), MAb, clone 2G1

Lipocalin-2(LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), 24p3, or neutrophil lipocalin (NL), is a 25-kDa secretory glycoprotein. 1 LCN2 has been implicated in a variety of cellular processes including the innate immune response, differentiation, tumorigenesis, and cell survival 2-3. It appears to be upregulated in various inflammation and infection conditions. Several reports suggest that LCN2 may represent a sensitive biomarker for various renal injuries4 and is associated with several types of cancers, including breast cancer,5 ovarian, colorectal, and pancreatic cancers. 6-7 Furthermore, a growing body of evidence suggests that serum levels of lipocalin-2 are correlated with obesity, insulin resistance, hyperglycemia, coronary heart disease and fatty liver disease in humans.8-11

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Recombinant full-length human lipocalin-2 in E.coli. (Cat. No: 41050).

The antibody detects human LCN2.

Mouse IgG1/ Kappa

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

Affinity chromatography on a column with immobilized protein G.

 

 

This antibody can be used as a capture antibody in a human Lipocalin-2 ELISA in combination with monoclonal anti-human Lipocalin-2 antibody clone 2C3 (Cat. No.: 21051)

Solution in PBS.

[1] Kjeldsen, L. et al. (1993) J. Biol. Chem. 268:10425-32 

[2] Yang, J. et al. (2002) Mol. Cell. 10:1045-56. 

[3] Flo, T.H. et al. (2004) Nature 432:917-21. 

[4] Mishra, J. et al. (2005) Lancet 365:1231-6. 

[5] Yang, J. et al. (2009) Proc Natl Acad Sci U S A 106(10):3913-8. 

[6] Hanai, J. et al. (2005) J. Biol. Chem. 280:13641-7. 

[7] Lee, H.J. et al. (2005) Int. J. Cancer 118:2490-7. 

[8] Wang Y, et al. (2007) Clin Chem 53(1):34-41. 

[9] Yan QW, et al. (2007) Diabetes 56(10):2533-40. 

[10] Ruby LC Hoo, et al. (2008) Expert Rev. Endocrinol Metal 3(1):29-41. [11] Milner KL, et al. Hepatology [Epub ahead of print]