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M-CSF, Human

M-CSF, Human

SKU: UA040042

★ Download Datasheet PDF ★

★ Download MSDS ★

 

 Species:

Human

Expression System:

E.coli

MW:

19 kDa (reducing)

Accession:

P09603-3

Cat No.

UA040042

Endotoxin:

1 EU/μg

Purity:

>95% as determined by SDS-PAGE

  • INTRODUCTION

    Macrophage-Colony Stimulating Factor (M-CSF), also known as Colony Stimulating Factor-1 (CSF-1), is a hematopoietic growth factor. It can stimulate the survival, proliferation and differentiation of mononuclear phagocytes, in addition to the spreading and motility of macrophages. M-CSF is mainly produced by monocytes, macrophages, fibroblasts, and endothelial cells. M-CSF interaction with its receptor, c-fms, has been implicated in the growth, invasion, and metastasis of several diseases, including breast and endometrial cancers. The biological activity of human M-CSF is only active in the disulfide-linked dimeric form, which is bonded at Cys63.

  • Amino Acid Sequence

    Glu33-Ser190
    MEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLV
    QDIMEDTMRFRDNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLE
    KVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQGHERQSEGS

  • Physical Appearance:

    Lyophilized powder

  • Buffer:

    50mM Tris, 300mM NaCl, pH8.0

  • Reconstitution:

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • Stability and Storage

    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
    • 1 week, 2 to 8 °C under sterile conditions after reconstitution.

    Note: Please avoid repeated freeze-thaw cycles

$999.00Price

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