Anti-human PAI-1 Antibody, Mouse mAb, clone 3H3
Monoclonal Antibody against Human PAI-1
Size: 0.1 mg
Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activator, playing a major role in fibrinolysis [1,2]. PAI-1 is mainly produced by the endothelium, but is also secreted by other tissue types, such as adipose tissue . It is normally present at low levels in plasma and tissue, but its expression and release are increased in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome . PAI-1 is also involved in the pathophysiology of renal, pulmonary, cardiovascular, and metabolic diseases [5-8]. Elevated local or systemic PAI-1 can also exacerbate such pathologic conditions.
Recombinant human PAI-1 expressed in E.coli.
The antibody detects human PAI-1.
Protein G affinity purification
Liquid in phosphate-buffered saline (PBS).
Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
This antibody can be used as a capture antibody in a human PAI-1 ELISA in combination with polyclonal anti-human PAI-1 antibody as detection antibody.
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