Anti-human RBP4 Antibody, Mouse mAb, clone 1A2

Anti-human RBP4 Antibody, Mouse mAb, clone 1A2

SKU: 21061

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Monoclonal Antibody against Human RBP4

Application: ELISA

Size: 0.1 mg

Host: Mouse

  • INTRODUCTION

    Retinol binding protein 4 (RBP4), originally known as a specific transport of retinol in blood, is also a novel inflammatory and insulin resistance marker. Serum RBP4 levels are elevated in insulin resistant mice and humans with obesity and type 2 diabetes. Animal experiments found that increased secretion of RBP4 might reduce insulin-dependent glucose uptake by muscle tissue by reducing the activity of phosphoinositide 3-kinase (PI(3)K), and increased hepatic glucose output by increasing the expression of the enzyme PEPCK2. Studies suggested that elevated serum RBP4 was associated with components of the metabolic syndrome, including increased body-mass index, waist-to-hip ratio, serum triglyceride levels and systolic blood pressure, and decreased high-density lipoprotein cholesterol levels. Furthermore, circulating RBP4 concentrations were associated with subclinical cardiovascular disease, which imply that RBP4 could be involved in the development of atherosclerosis.

  • IMMUNOGEN

    Recombinant human RBP4 (Cat. No. 41060) in E.coli.

  • SPECIFICITY

    The antibody detects human RBP4.

  • PURIFICATION

    Protein G affinity purification

  • FORMULATION

    Liquid in phosphate-buffered saline (PBS).

  • STORAGE

    Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • APPLICATION/USAGE

    This antibody can be used as a capture antibody in a human retinol binding protein 4 ELISA in combination with monoclonal anti-human retinol binding protein 4 antibody (Cat. No.: 21060) as detection antibody.

$200.00Price

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