Tumor Necrosis Factor alpha (TNF-α), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. TNFα activates signals through two receptors, TNFR1, which is expressed on most cell types, and TNF-R2, which is expressed mainly on immune cells.
Amino Acid Sequence
PBS, pH 7.4
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
- 1 week, 2 to 8 °C under sterile conditions after reconstitution.
Note: Please avoid repeated freeze-thaw cycles