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IL-33 strongly induces Th2 cytokine production from innate immune cells and T helper 2 (Th2) cells. and can promote the pathogenesis of Th2-related disease such as asthma, atopic dermatitis and anaphylaxis. However, IL-33 has shown various protective effects in cardiovascular diseases such as atherosclerosis, obesity, type 2 diabetes and cardiac remodeling. Thus, the effects of IL-33 are either pro- or anti-inflammatory depending on the disease and the model.

Interleukin-33 (IL33) cytokine is a member of the Interleukin-1 family. It can be classified as an alarmin due to being stored in epithelial cells, endothelial cells and fibroblasts; and is released upon tissue damage to mediate local immune activation. 

In mice, IL-33 was found to effect the production of methionine-enkephalin peptides in group 2 innate lymphocytes, in turn promoting the emergence of beige adipocytes, which leads to increased energy expenditure and decreased adiposity.

Administration of IL-33 to mice triggers a range of IL-13–dependent responses, but may also induce production of IL-4 and IL-5, either of which could modulate inflammation in adipose tissue. IL-33 has been shown to protect mice from the metabolic consequences of obesity.

ImmunoDiagnostics has developed a series of adiponectin-related products, such as ELISA Kits, ITA Assays and Antibodies, which have been used globally for over a decade.


Mouse IL-33



Bioactive proteins and antibodies

Mouse Anti-IL33, rabbit pAb

Human Interleukin-33 (IL-33)

Mouse Interleukin-33 (IL-33)

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