Thrombospondin-2 (TSP-2) is a 150 kDa calcium-binding protein. it is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.
Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.
TSP-2 inhibits angiogenesis through direct effect on endothelial cell migration, proliferation, survival and apoptosis. Meanwhile, Serum thrombospondin-2 (TSP-2) is a glycoprotein expressed in the extracellular matrix (ECM), which increases during tissue remodeling. It is a potential risk factor in heart disease. It has been shown in recent studies that TSP-2 is a useful predictor of cardiovascular death in patients with heart failure (HF).