CRP (human), MAb, clone 7E12

SKU: 21121

 

Application  :  ELISA detection

Size              :  1 mg

Human C-Reactive Protein (CRP) Mouse Monoclonal Antibody, clone: 7E12

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Cat. No.

Description

Host

Reactivity

Applications

21121

C-reactive protein, MAb, clone 7E12

Mouse

Human

ELISA detection

21120

C-reactive protein, MAb, clone 8G1

Mouse

Human

ELISA capture

31120

Human CRP ELISA kit, high sensitivity

0.78-50 ng/ml

31121

Human CRP ELISA kit, one-step

0.78-50 ng/ml

  • INTRODUCTION

    C-reactive protein (CRP) is a circulating protein mainly secreted from the liver. This acute phase protein consists of five identical non-glycosylated subunits of 23 kDa, that give rise to a symmetrically arranged globular protein with molecular weight of approximately 120 kDa.1 It has long been recognized that CRP is closely related to immunology, inflammation and host defense; as a result it has been used as an inflammatory marker. However, the development of high-sensitivity CRP (hsCRP) ELISA had addressed its role in other clinical issues. There is accumulating evidence suggesting the important role that CRP plays in mediating cardiovascular diseases (CVD) and type 2 diabetes.2-4 Normally CRP is presenting only in a trace amount in circulation (<1 g/ml)5-6 but can increase over 1,000-fold under acute inflammatory state. Individual with blood CRP levels <1 g/ml, 1-3 g/ml and >3 g/ml is considered to have low, moderate and high risk, respectively, of CVD and myocardial infraction.7 Therefore, blood CRP level has become a promising measure of CVD risk.8-9

  • DATA SHEET

  • IMMUNOGEN

    E.coli-derived recombinant human C-Reactive Protein (CRP)

  • HOST

    Mouse

  • ISOTYPE/ LIGHT CHAIN TYPE

    Mouse IgG1/Kappa

  • STORAGE

    Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • APPLICATION/ USAGE

    This antibody can be used as a detection antibody in a human CRP ELISA in combination with monoclonal anti-human CRP antibody (Cat. No.: 21120)

  • PURIFICATION METHOD

    Affinity chromatography on a column with immobilized protein G.

     

     

  • REFERENCES

    1. Thompson D., Pepys M.B. and Wood S.P. (1999) Structure, 7, 169-177.

    2. Festa A, D’Agostino R. Jr., Tracy R.P. and Haffner S.M. (2002) Diabetes, 51, 1131-1137.

    3. Verma S. and Yeh E.T. (2003) Am J Physiol, 285, R1253-R1258.

    4. Jialal I., Devaraj S. and Venugopal S.K. (2004) Hypertension, 44, 6-11.

    5. Kindmark C.O. (1972) Scand J Clin Lab Invest, 29, 407-411.

     

$200.00Price

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