Anti-human FABP4 Antibody, Rabbit pAb

Anti-human FABP4 Antibody, Rabbit pAb

SKU: 11030

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Polyclonal Antibody against Human FABP4

Application: WB, IP

Size: 0.1 mg

Host: Rabbit

  • INTRODUCTION

    Fatty-acid binding protein 4 (FABP4), also termed adipocyte fatty-acid binding protein (A-FABP), or aP2, is a novel adipocyte-expressed factor which accounted for ~6% of total cellular proteins. Several animal experiments suggested that FABP4 plays a key role in the link between obesity and various features of metabolic syndrome. Mice with targeted disruption of FABP4 accompany FABP5 almost completely to protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. Studies in human found FABP4 serum levels were significantly increased in overweight and obese subjects, which predicted the risk to develop metabolic syndrome and type 2 diabetes. Additionally, serum FABP4 levels were associated with carotid atherosclerosis and coronary artery disease.

  • IMMUNOGEN

    Recombinant full-length human FABP4 expressed in E.coli.

  • SPECIFICITY

    The antibody detects human FABP4.

  • FORMULATION

    Liquid in phosphate-buffered saline (PBS).

  • STORAGE

    Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • APPLICATION/ USAGE

    Western blot - This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect human FABP4.

  • PURIFICATION

    Rabbit crude IgG was purified by protein-G column.

  • PUBLICATIONS CITING THIS PRODUCT

    1. Elie AG, Jensen PS, Nissen KD, Geraets IM, Xu A, Song E, Hansen ML, Irmukhamedov A, Rasmussen LM, Wang Y, De Mey JG. Adipokine imbalance in the pericardial cavity of cardiac and vascular disease patients. PloS one. 2016 May 3;11(5):e0154693.
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