Human Retinol Binding Protein 4 (RBP4)
Retinol binding protein 4(RBP4), originally known as a specific transport of retinol in blood, is also an inflammatory and insulin resistance marker. Serum levels of RBP4 increased in insulin resistant and diabetes. Studies both in human and animal suggested that serum levels of RBP4 plays a key role in the link between obesity, insulin resistant and diabetes.
RBP4 is normally excreted into the urine but accumulate in the serum during renal failure. Elevated serum retinol-binding protein 4 concentrations are associated with chronic kidney disease.
Expressed in E.Coli. Mw: 24.4 kDa (calculated).
N-terminal 6xHis-tag and TEV cleavage site
Recombinant antigen for research use or manufacturing only.
Solution in PBS.
Standard ELISA test, Western blotting
QUALITY CONTROL TEST
BCA to determine quantity of the protein.
SDS-PAGE to determine purity of the protein.
Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
AMINO ACID SEQUENCE
MSYYHHHHHH DYDIPTTENL YFQGAMGSER DCRVSSFRVK ENFDKARFSG TWYAMAKKDP EGLFLQDNIV
AEFSVDETGQ MSATAKGRVR LLNNWDVCAD MVGTFTDTED PAKFKMKYWG VASFLQKGND DHWIVDTDYD
TYAVQYSCRL LNLDGTCADS YSFVFSRDPN GLPPEAQKIV RQRQEELCLA RQYRLIVHNG YCDGRSERNL L