top of page
Human β-Klotho (Human sKLB)

Human β-Klotho (Human sKLB)

SKU: 41C071

★ Download Datasheet PDF ★

 Origin:

Recombinant

Cat. No.:

41C071

Tag:

C-terminal 6xHis

Size:

0.1 mg

Source:

Human Embryonic Kidney Cells 293

Purity:

>95%

Synonyms:

Klotho β, KLB, BKL

Species:

Human

  • INTRODUCTION

    Human beta-klotho (β-Klotho) is a single-pass transmembrane protein that belongs to the klotho family, which also includes α-klotho and γ-klotho. β-Klotho is encoded by the KLB gene and is primarily expressed in the liver, white adipose tissue, brain, and other organs. It plays a crucial role in the activation of fibroblast growth factor (FGF) signaling pathways, specifically FGF19 and FGF21, by forming a complex with FGF receptors (FGFRs). Human beta-klotho is a multifunctional protein that plays a critical role in metabolism, anti-aging processes, tumor suppression, and neuroprotection by modulating FGF signaling pathways.

  • FORMULATION

    Lyophilized at 1 mg/mL in NaCl 300mM, KCl 2.7mM, Na2HPO4 10mM, KH2PO4
    1.8mM, pH 7.4.

  • APPLICATION/ USAGE

    Cell culture, animal studies, ELISA and Western blotting.

  • QUALITY CONTROL TEST

    BCA to determine quantity of the protein.
    SDS PAGE to determine purity of the protein.

  • STORAGE

    Store lyophilized protein at –20°C. Aliquot reconstituted protein and store at –80°C. Avoid repeated freezing/thawing cycles.

  • PUBLICATION

    1. Geng L, Yi X, Lin Y, Abulimiti X, Jin L,Yu J, Xu A. Site-specific analysis and functional characterization of N-linked glycosylation for β-Klotho protein. Int J Biol Macromol. 2024 Dec 19:289:138846.
$496.00Price
Quantity

The currency used on this website is United States Dollars (USD). All prices are displayed and transactions are processed in USD. For orders outside Hong Kong or if you would like to have other currencies available, please contact us for a quote.

bottom of page