Human Proteinase 3 (PR3)
Expressed in CHO cells with total 264 AA. Mw: 29 KDa (calculated).
C-terminal 10xHis-tag, 10 extra AA (highlighted).
Recombinant antigen for research use or manufacturing only.
|Chinese hamster ovary cells|
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease with increasing annual incidence, recently estimated at 20 per million per year. It is associated with antibodies to proteinase 3 or myeloperoxidase and is generally considered as a disease affecting small blood vessels (‘small vessel vasculitis’). PR3 antibodies are most commonly associated with granulomatous polyangiitis (GPA), with peak incidence in 50 to 70 years old and affecting more men than women. Thus, PR3-ANCAs are well-known serological markers for diagnosis of GPA.
Liquid in PBS. (137mM NaCl, 2.7mM KCl, 100mM Na2HPO4, 1.5mM KH2PO4, pH 7.4).
Standard ELISA test, line/dot assay and microarray assay with positive/negative sera panels.
Store at -20°C to -80°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freezing/thawing cycles.
AMINO ACID SEQUENCE