Humanized Monoclonal Antibody against SARS-CoV-2 S1RBD

Humanized Monoclonal Antibody against SARS-CoV-2 S1RBD

SKU: 41A245

 

 

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Cat. No.: 41A245                                 Size:  100µg

 

Type: Genetically engineered recombinant monoclonal IgG antibody

 

  • INTRODUCTION TO THE MOLECULE

    The SARS-CoV-2 glycosylated spike (S) protein highly exposed on the viral surface is a major determinant for virus binding and invasion into hose cells, which is a main target for neutralization antibody. The receptor-binding domain (RBD) in SARS-CoV-2 S protein is responsible for binding to human and bat angiotensin-converting enzyme 2 (ACE2) receptors.

  • PRODUCTION

    The cDNA encoding the highly variable region of the antibody recognizing S1RBD from mammalian cells were identified by phage display library, fused with the Fc fragment of human IgG1, and expressed in Chinese Hamster Ovary (CHO) cells.

  • FORMULATION, RECONSTITUTION AND STORAGE

    Lyophilized from sterile PBS, pH 7.4. Lyophilized protein can be stored at 2℃ to 8℃ for short-term, and at -20℃ to -80℃ for long term.  store. For reconstitution, add 100 μl of deionized water, mix gently and incubate the reconstituted product for 10 minutes at room temperature prior to use. Reconstituted protein should be kept at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

  • APPLICATION/USAGE

    ELISA and other applications. Optimal concentration/dilution should be determined by the end user.

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