Anti-human LCN2 Antibody, Mouse mAb, clone 2C3

Anti-human LCN2 Antibody, Mouse mAb, clone 2C3

SKU: 21051

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Monoclonal Antibody against Human LCN2

Application: ELISA

Size: 0.1 mg

Host: Mouse

  • INTRODUCTION

    Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), 24p3, or neutrophil lipocalin (NL), is a 25-kDa secretory glycoprotein [1]. LCN2 has been implicated in a variety of cellular processes including the innate immune response, differentiation, tumorigenesis, and cell survival [2-3]. It appears to be upregulated in various inflammation and infection conditions. Several reports suggest that LCN2 may represent a sensitive biomarker for various renal injuries [4] and is associated with several types of cancers, including breast cancer [5], ovarian, colorectal, and pancreatic cancers [6-7]. Furthermore, a growing body of evidence suggests that serum levels of LCN2 are correlated with obesity, insulin resistance, hyperglycemia, coronary heart disease and fatty liver disease in humans [8-11].

  • IMMUNOGEN

    Recombinant full-length human lipocalin-2 (Cat. No: 41050) in E.coli.

  • SPECIFICITY

    The antibody detects human LCN2.

  • PURIFICATION

    Protein G affinity purification

  • FORMULATION

    Liquid in phosphate-buffered saline (PBS).

  • STORAGE

    Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

  • APPLICATION/USAGE

    This antibody can be used as a capture antibody in a human lipocalin-2 ELISA in combination with monoclonal anti-human lipocalin-2 antibody clone 2C3 (Cat. No.: 21050) as detection antibody.

  • REFERENCES

    [1] Kjeldsen, L. et al. (1993) J. Biol. Chem. 268:10425-32

    [2] Yang, J. et al. (2002) Mol. Cell. 10:1045-56.

    [3] Flo, T.H. et al. (2004) Nature 432:917-21.

    [4] Mishra, J. et al. (2005) Lancet 365:1231-6.

    [5] Yang, J. et al. (2009) Proc Natl Acad Sci U S A 106(10):3913-8.

    [6] Hanai, J. et al. (2005) J. Biol. Chem. 280:13641-7.

    [7] Lee, H.J. et al. (2005) Int. J. Cancer 118:2490-7.

    [8] Wang Y, et al. (2007) Clin Chem 53(1):34-41.

    [9] Yan QW, et al. (2007) Diabetes 56(10):2533-40.

    [10] Ruby LC Hoo, et al. (2008) Expert Rev. Endocrinol Metal 3(1):29-41.

    [11] Milner KL, et al. Hepatology [Epub ahead of print].

$200.00Price

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